Alpha Lipoic Acid Benefits: Help Improve Insulin Sensitivity & Fight Diabetes (2023)

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By Jillian Levy, CHHC

June 5, 2022

(Video) Alpha Lipoic Acid Improve Insulin Sensitivity & Fight Diabetes!
Alpha Lipoic Acid Benefits: Help Improve Insulin Sensitivity & Fight Diabetes (1)

What is it about foods like broccoli and spinach that make them so healthy? There are the fiber, vitamins and minerals, of course, but then there are other important chemical compounds we call “antioxidants,” too — including alpha lipoic acid (ALA).

Chances are you’ve heard a lot about the many benefits of various antioxidants and high-antioxidant foods — fighting inflammation, helping to beat cancer and so much more — but have you ever wondered what exactly antioxidants are and how they work in the body?

Alpha lipoic acid — one kind of antioxidant — isa type of compound found in plant foods we commonly eat.

What is alpha-lipoic acid good for? It helps scavenge free radicals and slows the aging process — but perhaps its most famous use is in helping treat diabetes naturally.

Humans make a small amount of ALA on their own, although the concentration in our bloodstreams goes up substantially when we eat a healthy diet. It’s naturally abundant in foods like green veggies, potatoes and certain types of yeast — plus it can be man-made in a lab and taken as an oral anti-inflammatory supplement.

What Is Alpha Lipoic Acid?

Alpha lipoic acid (also called lipoic acid or thioctic acid) is an organosulfur compound found in the body and also synthesized by plants and animals. It’s present in every cell inside the body and helps turn glucose into “fuel” for the body to use for energy.

Is it “essential” that you consume a certain dosage of alpha lipoic acid every day? Not exactly, which is why it’s not considered an “essential nutrient.”

Even though we can make some of it on our own without supplements or outside food sources, eating an antioxidant-packed diet plus potentially using ALA supplements can increase the amount circulating in the body. Studies show this can have far-reaching benefits.

ALA’s most valuable role in the body is fighting the effects of free radicals, which are dangerous, chemical-reaction byproducts that form during the process of oxidation. Within our cells, ALA is converted into dihydrolipoic acid, which has protective effects over normal cellular reactions, such as those involved inmetabolic functions and neuron signaling.

Like other antioxidants, alpha lipoic acid can help slow down cellular damage that is one of the root causes of diseases. It also works in the body to restore essential vitamin levels, such as vitamin E and vitamin C, and acts as acofactor for several important mitochondrial enzymes. Additionally, it helps the body digest and utilize carbohydrate molecules.

Something that makes ALA unique is that it’s both water-soluble and fat-soluble, unlike other nutrients (like B vitamins or vitamin A, C, D or E). This means it can be properly absorbed despite what types of foods you’re eating, and it can be used in almost all parts of the body.

Note: Alpha lipoic acid is not the same thing asalpha linolenic acid, a type of omega-3 fatty acid. Both are sometimes referred to as ALA, which can be confusing, but they’re two different nutrients with different roles in the body.

ALA Benefits

1. Has Anti-Inflammatory and Antioxidant Effects

Because it acts like an antidote to oxidative stress and inflammation, alpha lipoic acid seems to fight damage done to the blood vessels, brain, neurons and organs, like the heart or liver.

Being low in antioxidants in general can speed up in the aging process, resulting in symptoms like a weakened immune function, decreased muscle mass, cardiovascular problems and memory problems.

(Video) Why Alpha Lipoic Acid Improve Insulin Sensitivity and Fight Diabetes!

There’s some evidence that ALA is acts as a “heavy metal chelator,” binding to metals (also called “toxins”) in the body, including mercury, arsenic, iron and other forms of free radicals that make their way into the bloodstream through water, air, chemical products and the food supply.

Finally, alpha lipoic acid can increase how the body uses a very important antioxidant known as glutathione.

2. Fights Diabetes and Diabetic Complications

Alpha lipoic acid can protect cells and neurons involved in hormone production, offering protection against type 2 diabetes.

Alpha lipoic acid supplementation seems to help improve insulin sensitivity and might also offer protection against metabolic syndrome— a term given to a cluster of conditions like high blood pressure, cholesterol and body weight. Some evidence also shows that it can help lower blood sugar levels.

A 2012 systematic review and meta-analysis, along with a 2013 controlled clinical trial, showed that ALA is an effective drug in the treatment of diabetic neuropathy, which affects about 50 percent of people with diabetes. Diabetic neuropathy (nerve damage) causes symptoms like tingling, numbness and burning in the limbs. About 300–600 milligrams per day in IV form has been shown to be beneficial.

ALA is used to help relieve other complications and symptoms of type 2 diabetes too, such as cardiovascular problems, eye-related disorders, pain and swelling. That’s why it should be part of any diabetic diet plan to treat this common disorder.

Most studies show that high doses of ALA in IV form are more effective than eating ALA-rich foods.

According to a randomized, double-blind, placebo-controlled clinical trial, ALA also offers help in managing idiopathic pain(pain of unknown origin)in people without diabetes.

A major benefit of alpha lipoic supplementation in diabetics is the lowered risk for neuropathic complications that affect the heart, since around 25 percent of people with diabetes develop cardiovascular autonomic neuropathy (CAN). CAN is characterized by reduced heart rate variability and is associated with an increased risk of mortality in people with diabetes.

3. Preserves Eye Health

Oxidative stress can damage nerves in the eyes and cause vision problems, especially in people with diabetes or older adults. Alpha lipoic acid is used to help control symptoms of eye-related disorders, including vision loss, macular degeneration, retina damage, cataracts, glaucoma and Wilson’s disease.

Results from certain studies demonstrate that long-term use of ALA can halt oxidative damage that can result in modified DNA in the retina. As people age, their vision becomes much more compromised, which is why it’s important to eat a nutrient-dense diet well before old age to prevent degeneration of eye tissue or vision loss early on.
Alpha Lipoic Acid Benefits: Help Improve Insulin Sensitivity & Fight Diabetes (2)

4. Helps Prevent Memory Loss and Cognitive Decline

We know that an anti-inflammatory diet filled with various colorful “brain foods” helps protect memory. Some health care professionals use alpha lipoic acid supplements to further help prevent their patients from experiencing neuron damage, memory loss, motor impairment and changes in cognitive functioning due to its antioxidant activity.

ALA seems to easily make its way into the brain by passing the blood-brain barrier, where it canprotect delicate brain and nerve tissue. It’s also used to prevent strokes and other brain problems, including dementia in older adults.

Recent experiments using rats have shown that ALA can help reverse damage in aging cells of the brain, improve performance in memory tasks, lower oxidative damage and improve mitochondrial function, although we still don’t know how well these benefits can apply to aging humans.

(Video) The 8 Benefits of Alpha-Lipoic Acid

5. Helps Boost Glutathione

Glutathioneis considered the “master antioxidant” by many experts, since it’s crucial for immunity, cellular health and disease prevention.

One randomized, controlled trial found that 300–1,200 milligrams of alpha lipoic acid helps increase the ability of glutathione to regulate the body’s immune response. This may help fight off diseases, such as type 2 diabetes/insulin resistance and even HIV/AIDS.

Another meta-analysis found that supplementation made a significant difference in increasing glutathione levels, although this didn’t necessarily transfer to protection against diseases development.

In adults, alpha lipoic acid supplementation also seems to positively impact patients with immune deficiency syndromes and serious viruses. It does this by restoring blood total glutathione levels and improving functional reactivity of lymphocytes to T-cell mitogens. (These are cells in the immune system that fight pathogens.)

6. Might Help Protect Skin from Damage

When it comes to battling physical signs of aging on the skin, certain studies have found that topical treatment creams containing 5 percent alpha lipoic acid can help reduce fine lines caused by exposure to sun ways. ALA is thought to act as an anti-aging substance because it helps restore skin tissues and epidermal structure while battling free radicals.

A 2017 placebo-controlled clinical trial concluded that “5% Cubosomal ALA is an effective and safe modality for improving aging face.” When adult women applied an ALA treatment to one side of their faces for six months, the majority experienced significant improvements, including increased epidermal thickness, which contributes to skin’s texture and tone.

7. Supports a Healthy Metabolism, Body Weight and Energy Levels

Due to its ability to help convert foods into nutrients, ALA may help increase energy metabolism, which is why some athletes use ALA supplements for enhanced physical performance.

A 2020 meta-analysis of placebo-controlled trials also found that ALA treatment significantly reduced BMI and body weight and may protect against obesity. Similarly, a 2017 double-blind, placebo-controlled trial found that oral administration of ALA (1,200 mg/day) for eight weeks induced mild weight loss accompanied by a reduction in waist circumference.

Risks and Side Effects

What are the side effects of taking alpha lipoic acid? Side effects of ALA in supplement form are generally rare, but for some people they can include:

  • insomnia
  • fatigue
  • diarrhea
  • skin rash
  • low blood sugar levels (especially in people with diabetes or low blood sugar who take medications)

Alpha lipoic acid supplements haven’t been studied in children or women who are pregnant or breastfeeding, so right now they’re intended for use in adults only.

How to Take It

Food Sources:

The best way to get any nutrients is ideally through real food sources, since this is how your body knows how to absorb and use various chemicals best. ALA is found in many different plant and animal sources, since it’s bound to protein molecules (especially lysine).

The concentration of ALA in different foods can vary widely depending on where they’re grown, the quality of the soil, how fresh they are and how they’re prepared, so it’s hard to quantify how much is in each type of food. There hasn’t been much research done to draw conclusions about how much ALA is found in particular foods, although we know vegetables and certain organ meats seem to be highest.

That being said, when you eat a whole food-based diet and vary the types of things you eat, chances are you consume a decent amount in addition to what your body already makes on its own.

(Video) The Amazing Benefits of Alpha-Lipoic Acid

Here are some of the best food sources of alpha lipoic acid:

  • Broccoli
  • Spinach
  • Red meat
  • Organ meat (such as liver, hearts, kidneys from beef or chicken)
  • Brussels sprouts
  • Tomatoes
  • Peas
  • Brewer’s yeast
  • Beets
  • Carrots


Alpha lipoic acid supplements are available in both capsule and injection forms.

According to researchers from Oregon State University, the amounts of lipoic acid available in dietary supplements (ranging in dosage from 200–600 milligrams) can be as much as 1,000 times greater than the amounts that could be obtained through someone’s diet alone.

Taking oral ALA supplements with a meal is believed to decrease its bioavailability, so most experts recommend taking it on an empty stomach (or at least one hour before or after) for the best results.

How do you know if you should take ALA supplements? For example, what are symptoms of alpha-lipoic acid deficiency?

Most people make enough to prevent a deficiency, although supplements can be helpful for those prone to diabetes, stroke, heart disease or glaucoma.

A true lipoic acid deficiency (called lipoic acid synthetase deficiency) is a rare type of neurometabolic disease. It’s characterized by symptoms including seizures, problems with muscular growth and control, feeding difficulties, and psychomotor delays.

When someone has this disease, that person works with a doctor to help treat symptoms using supplementation.

Dosage Recommendations:

Because ALA isn’t an official essential nutrient, there hasn’t been an established daily recommendation needed to prevent a deficiency.

A general dosage recommendation for alpha lipoic acid supplementation is between20–50 milligrams per day for adults. This amount seems to be beneficial for general preventative health.

Larger doses up to 600–800 milligrams per day are sometimes used in patients with diabetes or cognitive disorders but not recommended for the general public.

Dosage recommendations differ depending on whom you ask, but below are some general guidelines that are within the safe range:

(Video) The 2 Most Ignored Minerals In Diabetes and Insulin Resistance – Dr.Berg

  • 50–100 milligrams for antioxidant purposes in generally healthy adults
  • 600–800 milligrams for patients with diabetes (divided into two doses, usually tablets are30–50 milligrams each)
  • 600–1,800 milligrams for patients with neuropathy and diabetic neuropathy (dosages this high should only be taken with supervision from a doctor)

Drug Interactions

Who should not take alpha lipoic acid? Some potential interactions, or circumstances where you want to speak to your doctor before taking extra alpha lipoic supplements, include:

  • You have athiamine deficiency (vitamin B1), which is associated with liver disease/alcohol abuse.
  • You’re taking any medications for diabetes for insulin control, since this can raise the risk forhypoglycemia and low blood sugar.
  • You’re recovering from chemotherapy treatment or taking cancer medications.
  • You have a history of a thyroid disorder and take thyroid medications, including Levothyroxine.


  • Alpha lipoic acid (also called ALA or thioctic acid) is a type of compound found in many plant foods and in supplement form. The body also makes some ALA on its own.
  • Its main jobs include having antioxidant effects, fighting free radicals and converting nutrients into energy.
  • It also has anti-inflammatory effects, meaning ALA offers protection againstdiabetic neuropathy, metabolic syndrome, vision loss, skin changes and other age-related problems.
  • For most people, it’s best to get this compound from a healthy diet, especially foods like broccoli, spinach, other greens, beets, carrots, meat and organ meats.
  • Alpha lipoic acid supplementation is sometimes recommended for people prone to diabetes complications, stroke or other issues. It can be taken in capsule or IV form.


Does alpha-lipoic acid improve insulin sensitivity? ›

Alpha-lipoic acid (ALA), a naturally occuring compound and a radical scavenger was shown to enhance glucose transport and utilization in different experimental and animal models. Clinical studies described an increase of insulin sensitivity after acute and short-term (10 d) parenteral administration of ALA.

Does alpha-lipoic acid help with diabetes? ›

Diabetes. Several studies suggest alpha-lipoic acid helps lower blood sugar levels. Its ability to kill free radicals may help people with diabetic peripheral neuropathy, who have pain, burning, itching, tingling, and numbness in arms and legs from nerve damage.

How much alpha lipoic should a diabetic take? ›

For the treatment of diabetes, the recommended dosage of LA is 300–600 mg daily. For general antioxidant support, the dosage is 20–50 mg daily.

How long does it take for alpha-lipoic acid to work for diabetes? ›

In studies on diabetic autonomic neuropathy, effects of alpha lipoic acid were seen after 8–16 weeks [21, 22], depending on the study design.

Does alpha-lipoic acid reduce A1C? ›

A 2018 review of 20 randomized controlled trials looked at ALA use in people with metabolic disorders, including type 2 diabetes. Results showed ALA supplementation lowered fasting blood glucose, insulin concentration, insulin resistance, and hemoglobin A1C levels.

How can I restore my insulin sensitivity? ›

Here are 14 natural, science-backed ways to boost your insulin sensitivity.
  1. Get more sleep. A good night's sleep is important for your health. ...
  2. Exercise more. ...
  3. Reduce stress. ...
  4. Lose a few pounds. ...
  5. Eat more soluble fiber. ...
  6. Add more colorful fruit and vegetables to your diet. ...
  7. Cut down on carbs. ...
  8. Reduce your intake of added sugars.

How long does it take to see benefits of alpha-lipoic acid? ›

Just five weeks of oral supplementation with lipoic acid significantly improved the stabbing pain, burning pain, and numbness of the feet in patients suffering from diabetic neuropathy, with the dose-effectiveness range being 600-1,800 mg of lipoic acid dosed orally per day.

What's the best time to take alpha-lipoic acid? ›

Alpha-lipoic supplements are best taken on an empty stomach, as certain foods can lower the acid's bioavailability (40). Though there is no set dosage, most evidence suggests that 300–600 mg is sufficient and safe.

Can I take alpha-lipoic acid every day? ›

Dosing. Alpha-lipoic acid has most often been used by adults in doses of 600-1800 mg by mouth daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Is alpha-lipoic acid hard on kidneys? ›

But alpha lipoic acid plays another critical role—protecting your cells from oxidative damage, including those in your kidneys.

What vitamins should not be taken with alpha-lipoic acid? ›

What should I avoid while taking alpha-lipoic acid? Avoid using alpha-lipoic acid together with other herbal/health supplements that can also lower your blood sugar. This includes devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, and Siberian ginseng.

Who should not take lipoic acid? ›

Do not take alpha-lipoic acid without medical advice if you are using any of the following medications: insulin or oral diabetes medicine; medicines to treat underactive thyroid, such as levothyroxine (Synthroid) and others; or. cancer medicines (chemotherapy).

How much alpha-lipoic acid should I take daily for neuropathy? ›

Because alpha-lipoic acid is an unproven treatment, there is no established dose. However, studies have used between 600-1,800 milligrams daily for diabetes and neuropathy; one review concluded that the evidence is convincing for the use of 600 milligrams daily for three weeks on symptoms of diabetic neuropathy.

Can alpha-lipoic acid reverse neuropathy? ›

Alpha-lipoic acid seems to delay or reverse peripheral diabetic neuropathy through its multiple antioxidant properties. Treatment with alpha-lipoic acid increases reduced glutathione, an important endogenous antioxidant. In clinical trials, 600 mg alpha-lipoic acid has been shown to improve neuropathic deficits.

Is alpha-lipoic acid worth taking? ›

Research suggests that ALA may help with weight loss, diabetes, memory loss, and some other health conditions. However, there is not enough research to understand its full benefits or effectiveness in humans. ALA is generally safe for adults, but it is best to speak with a doctor before taking any new supplements.

What is the best vitamin to lower A1C? ›

Vitamin D

After two months of taking a 4,500-IU supplement of vitamin D daily, both fasting blood sugar and A1C improved. In fact, 48% of participants had an A1C that showed good blood sugar control, compared to only 32% before the study ( 20 ).

What is the best pill to lower A1C? ›

Metformin is considered the first-line oral agent for patients with diabetes and can be used to treat pre-diabetes. It works by decreasing glucose production in the liver, increasing insulin sensitivity, and lowering intestinal sugar absorption.

What lowers A1C the fastest? ›

7 Ways to Improve Your A1C
  • Exercise. Physical activity helps your body use insulin more efficiently, so it can better process the glucose in your blood. ...
  • Eat Right. ...
  • Take Medications as Prescribed. ...
  • Manage Your Stress. ...
  • Stick to a Schedule. ...
  • Drink in Moderation. ...
  • Monitor Your Numbers.

What Vitamin increases insulin sensitivity? ›

[1,2] Vitamin D increases insulin sensitivity through the effect on its muscle cell receptors by increasing insulin receptor or increasing the sensitivity of insulin receptor to insulin and the effect on peroxisome proliferator-activated receptor (PPAR) δ and the influence on regulation of extracellular calcium.

What is good for insulin sensitivity? ›

Physical activity: Getting regular amounts of moderate-intensity physical activity helps increase glucose energy usage and improve muscle insulin sensitivity. A single session of moderate-intensity exercise can increase glucose uptake by at least 40%.

How quickly can you improve insulin sensitivity? ›

In a recent study of previously sedentary people with Type 2 diabetes, four to six weeks of moderate-intensity resistance training improved their insulin sensitivity by 48%, even without causing any significant changes in their body fat or muscle mass.

Does alpha-lipoic acid help hair growth? ›

Normally used for hair loss, Alpha-Lipoic Acid can prevent the further receding of the hairline by acting as an antioxidant and blocking enzymes that can threaten our hair's roots in general. This herb can help stimulate hair growth and prevent further hair loss.

Does alpha-lipoic acid cleanse the liver? ›

ALA helps with the treatment of liver damage, diabetes, cancer, and other diseases. Alpha Lipoic Acid can be used as an oral supplement or taken intravenously. It is believed that Alpha Lipoic Acid administered intravenously will assist in the detox of the liver and its regeneration.

Does alpha-lipoic acid raise blood pressure? ›

Alpha-lipoic acid supplementation significantly reduced SBP (SMD = –0.50, 95% CI: –0.84, –0.16, p = 0.004) and DBP (SMD = –0.40, 95% CI: –0.71, –0.09, p = 0.01), compared to the controls, with the reduction of 6.1 mm Hg and 3.6 mm Hg of the mean SBP and DBP, respectively.

What does alpha-lipoic do for your body? ›

Alpha-lipoic acid is good for the heart and could benefit those with cardiovascular disease. “Studies have suggested that alpha-lipoic acid may reduce the risk of a number of cardiovascular issues by improving blood cholesterol levels, reducing stroke risk, and protecting endothelial cells,” says Dr. Sherpa.

Can I take vitamin B12 and alpha-lipoic acid together? ›

Interactions between your drugs

No interactions were found between alpha-lipoic acid and Vitamin B12. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

How long should I wait to eat after taking alpha-lipoic acid? ›

A study suggests that ALA bioavailability is greatly reduced after food intake and it has been recommended that ALA should be admitted at least 2 h after eating or if taken before; meal should be taken at least 30 min after ALA administration [92].

Is ALA good for your liver? ›

ALA is a powerful antioxidant effects on fatty liver. ► ALA prevents degenerations and induces liver regeneration. ► ALA induces liver regeneration by inhibiting apoptosis.

Can alpha-lipoic acid affect your heart? ›

Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling.

Does alpha-lipoic acid tighten skin? ›

However, you can use alpha-lipoic acid for skin to slow down and minimize the appearance of fine lines and wrinkles. This potent anti-aging ingredient can tighten the skin, improve its firmness, and keep it youthful.

Does alpha-lipoic acid shorten lifespan? ›

Alpha-lipoic acid and longevity

Animal studies show that alpha-lipoic acid prolonged lifespan in certain species [24] but reduced it in progeric mice [25]. There is currently no data supporting such an effects on human lifespan, and studies of the long-term effects on health have not been conducted.

What happens if you take too much alpha-lipoic acid? ›

Although ALA intoxication is very rare, it is sometimes seen after accidental or suicidal acute ingestion. Neurologic effects, metabolic acidosis, and t wave inversions in the EKG are observed when this acute poisoning occurs. Supportive treatment should be the main therapy.

How does alpha-lipoic acid affect the brain? ›

Preclinical research suggests that ALA scavenges free radicals, reduces inflammation, and may protect brain cells from conditions such as stroke, multiple sclerosis, and Alzheimer's disease.

What can you not mix with alpha-lipoic acid? ›

Avoid using alpha-lipoic acid together with other herbal/health supplements that can also lower your blood sugar. This includes devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, and Siberian ginseng.

Can I take magnesium and alpha-lipoic acid together? ›

Combined intake of α-lipoic acid and magnesium results in reinforcement of the protective effect; especially, it increases antioxidant defense.

Can alpha-lipoic acid affect thyroid? ›

Possible Interactions with: Alpha-Lipoic Acid

Thyroid-regulating medications, Levothyroxine -- Apha-lipoic acid may lower levels of thyroid hormone. Blood hormone levels and thyroid function tests should be monitored closely in people taking thyroid hormones who are also taking alpha-lipoic acid.

Can I take alpha-lipoic acid with metformin? ›

METFORMIN HYDROCHLORIDE+ALPHA LIPOIC ACID is safe if used in the dose and duration recommended by your doctor.

What improves diabetic neuropathy? ›

Control blood sugar levels — An important treatment for diabetic neuropathy is to control blood sugar levels. Symptoms of pain and burning may improve when blood glucose sugar improves.

What form of alpha-lipoic acid is best? ›

A liquid formulation of R-lipoic acid was found to be better absorbed and more stable in the plasma, suggesting that it might be more efficacious than the solid form in the management of a condition like diabetic neuropathy (9, 10). There may also be differences in bioavailability of the two isomers of lipoic acid.

What vitamins should diabetics avoid? ›

Here are the harmful supplements for diabetics:
  • 1- Chromium: Even though studies have suggested that chromium may help keep blood sugar in check, it will not help you if you aren't deficient in this mineral. ...
  • 2- Vitamin E: ...
  • 3- Vitamin B: ...
  • 4- Magnesium:
Jan 9, 2023

What Vitamin gets rid of neuropathy? ›

B vitamins are known for their ability to support healthy nervous system function. Vitamins B-1, B-6, and B-12 have been found to be especially beneficial for treating neuropathy. Vitamin B-1, also known as thiamine, helps to reduce pain and inflammation and vitamin B-6 preserves the covering on nerve endings.

Which vitamin is best for nerve repair? ›

At high doses, methylcobalamin, the active form of vitamin B12, accelerated nerve regeneration, increased myelination, and improved motor and functional recovery of injured nerves [80, 83].

How much alpha-lipoic acid should a diabetic take? ›


For the treatment of diabetes, the recommended dosage of LA is 300–600 mg daily. For general antioxidant support, the dosage is 20–50 mg daily.

Which drugs improve insulin sensitivity? ›

There are two drugs in this class: pioglitazone (Actos) and rosiglitazone (Avandia). They help your cells use insulin better and lower the amount of glucose your liver makes.

What drugs reduce insulin sensitivity? ›

Medications that reduce insulin resistance (insulin-sensitizing and antihyperglycemic effects) include metformin and the thiazolidinediones. Metformin is a biguanide; it reduces hepatic glucose output and increases the uptake in the peripheral tissues (muscle and adipocytes).

What Vitamin affects insulin sensitivity? ›

In humans, it has been shown by majority of observational studies, that vitamin D is positively correlated with insulin sensitivity and its role is mediated both by direct mechanism through the availability of vitamin D receptors in several tissues and indirectly through the changes in calcium levels.

What vitamin helps reduce insulin resistance? ›

Another study tied higher vitamin D to a lower risk of insulin resistance, when the body is unable to respond to or use the insulin that it's producing.

How did diabetics survive before insulin? ›

Before insulin was discovered in 1921, people with diabetes didn't live for long; there wasn't much doctors could do for them. The most effective treatment was to put patients with diabetes on very strict diets with minimal carbohydrate intake. This could buy patients a few extra years but couldn't save them.

What can I take instead of metformin for insulin resistance? ›

Other alternatives to metformin
  • Avandia (rosiglitazone)
  • Nesina (alogliptin)
  • Tanzeum (albiglutide)
  • Jardiance (empagliflozin)
  • Invokana (canagliflozin)
  • Farxiga (dapagliflozin)
Mar 21, 2022

Which organ is most sensitive to insulin? ›

The brain as an insulin-sensitive metabolic organ.

What are the best insulin resistance supplements? ›

Supplements high in magnesium, berberine, chromium and resveratrol improve insulin sensitivity. Fenugreek, turmeric, ginger, and garlic are a few herbs and spices that have had potential outcomes for improving insulin sensitivity.

What causes extreme insulin sensitivity? ›

What Causes Insulin Resistance? It isn't clear exactly what causes insulin resistance, but a family history of type 2 diabetes, being overweight (especially around the waist), and being inactive all can raise the risk. You do not have to be overweight to have insulin resistance.

Which mineral increases insulin sensitivity? ›

Magnesium is a cofactor required for movement of glucose into the cell and for carbohydrate metabolism. It is involved in the cellular activity of insulin. Low magnesium intake is a risk factor for diabetes [92].

Can vitamin D reverse diabetes? ›

Evidence indicates that vitamin D treatment improves glucose tolerance and insulin resistance. Vitamin D deficiency leads to reduced insulin secretion. Supplementation with vitamin D has been shown to restore insulin secretion in animals.

How can I get my A1C down quickly? ›

7 Ways to Improve Your A1C
  1. Exercise. Physical activity helps your body use insulin more efficiently, so it can better process the glucose in your blood. ...
  2. Eat Right. ...
  3. Take Medications as Prescribed. ...
  4. Manage Your Stress. ...
  5. Stick to a Schedule. ...
  6. Drink in Moderation. ...
  7. Monitor Your Numbers.

What is the fastest way to cure insulin resistance? ›

What can you do about it?
  1. Getting active is probably the best way to combat insulin resistance. Exercise can dramatically reduce insulin resistance in both the short and long terms. ...
  2. Weight loss can also cut down on insulin resistance. ...
  3. No medications are specifically approved to treat insulin resistance.

How do I break insulin resistance quickly? ›

Fasting for at least 16 hours gives the body a chance to rest and allows blood levels of insulin to drop significantly. Not only does this help burn fat, it can also lower your risk of disease, particularly diabetes and pre-diabetes.


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